Chromosome changes in a brain metastasis of a large cell lung cancer

Direct chromosome preparations were made on a brain metastasis of a large cell lung cancer from a 46-year-old female patient. In the 169 cells examined, the modal chromosomes number was 73, and the majority (53.2%) of mitoses were in the near-triploid region. The tumor cells showed considerable heterogeneity in chromosome number and content. Chromosomes 3, 4, and 5 were the most frequently involved in aberrations. The mean number of unidentified marker chromosomes was five per mitosis.