Molecularly imprinted polymer based enantioselective sensing devices: a review

Area of Science:

• Analytical Chemistry
• Biochemistry
• Materials Science

Background:

• Chiral recognition is vital in biological systems and pharmaceutical analysis due to differing enantiomer activities.
• Effective chiral recognition relies on specific interactions between chiral compounds and selectors, often involving at least three binding centers.
• Molecular imprinting technology offers a method to create tailored 3D cavities for specific molecular recognition.

Purpose of the Study:

• To provide a comprehensive review of molecular imprinting technology for chiral sensor development.
• To guide researchers in designing rational chiral sensors based on molecular imprinting.
• To cover various transduction principles for detecting chiral compounds.

Main Methods:

• Review of literature on molecular imprinting technology for chiral recognition.
• Analysis of different transduction principles (electrochemical, piezoelectric) in chiral sensors.
• Discussion of the design principles for creating selective chiral recognition sites.

Main Results:

• Molecular imprinting technology has significantly advanced the field of chiral sensor development.
• Tailored 3D cavities created by molecular imprinting enhance selectivity in chiral recognition.
• The review highlights the potential of molecularly imprinted polymers in creating novel chiral sensors.

Conclusions:

• Molecular imprinting technology is a powerful tool for developing advanced chiral sensors.
• These chiral sensors have significant applications in pharmaceutical analysis and understanding life processes.
• The rational design of molecularly imprinted chiral sensors represents a promising trend in analytical chemistry.