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The Influence of the Reference Values on the Interpretation of Lung Function in Children: Comparison of Global Lung

Joanna Peradzyńska1, Katarzyna Krenke, Anna Szylling

  • 1Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland.

Advances in Experimental Medicine and Biology
|December 4, 2014
PubMed

Insights

New Global Lung Initiative (GLI) reference values identify more lung function abnormalities in Polish children compared to older Polish-1998 values. This impacts pediatric spirometry interpretation and diagnosis.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Diagnostics

Background:

  • Spirometry interpretation relies heavily on predicted reference values.
  • The Global Lung Initiative (GLI)-2012 provides updated reference values.
  • The impact of GLI-2012 on pediatric spirometry in Poland requires evaluation.

Purpose of the Study:

  • To compare spirometry interpretation using GLI-2012 versus Polish-1998 reference values in children.
  • To assess the diagnostic yield of GLI-2012 for lung function abnormalities in a pediatric cohort.

Main Methods:

  • Analysis of spirometry results from 315 Caucasian children aged 4-18.
  • Defined airway obstruction as FEV1/FVC < LLN and restrictive pattern as FVC < LLN and FEV1/FVC > LLN.
  • Compared z-scores and prevalence of ventilatory patterns between GLI-2012 and Polish-1998 values.

Main Results:

  • Significant differences observed in mean FEV1 and FVC z-scores between GLI-2012 and Polish-1998 (p<0.05).
  • No significant difference in FEV1/FVC z-scores.
  • GLI-2012 identified higher rates of obstructive (20.3% vs. 17.5%) and restrictive (7.6% vs. 3.8%) patterns.

Conclusions:

  • GLI-2012 reference values increase the detection of lung function abnormalities in Polish children compared to Polish-1998 values.
  • Updated reference values are crucial for accurate pediatric respiratory assessment.
  • Consideration of GLI-2012 is recommended for improved spirometry interpretation in this population.

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