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Updated: Apr 20, 2026

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
Published on: January 19, 2024
Glioblastoma in the elderly
1Department of Neurology and Neurological Surgery, University of Washington/Fred Hutchison Cancer Research Center, Seattle Cancer Care Alliance, 825 Eastlake Ave East MS G4940, Box 19023, Seattle, WA, 98109, USA, chambemc@uw.edu.
Abstract:
There is no generally agreed upon standard of care treatment for elderly patients (age ≥70 years) with glioblastoma (GBM). Treatment options range from supportive care only, radiation therapy (RT) only (most often given in a shortened hypofractionated schedule), temozolomide (TMZ) chemotherapy only, and the combination RT + TMZ, followed by post-RT TMZ as is the current standard of care for younger good performance patients with newly diagnosed GBM.
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