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Updated: Apr 20, 2026

Author Spotlight: Advancements in iPSCs and Genetic Disease Research
Published on: October 20, 2023
Differentiation of iPSC to Mesenchymal Stem-Like Cells and Their Characterization
Kim Hynes1,2,3, Danijela Menicanin4,5,6, Stan Gronthos5,6
1Colgate Australian Clinical Dental Research Centre, School of Dentistry, University of Adelaide, Adelaide, SA, Australia. kim.hynes@adelaide.edu.au.
Abstract:
Mesenchymal stem cells (MSC) are a unique population of adult stem cells that have the capacity to differentiate into numerous cell types as well as the ability to modulate the immune system. As such, MSC represent a promising stem cell population for use in the clinical treatment of a range of disorders involving tissue regeneration as well as the immune system. The lack of accessibility to MSC is currently limiting the use of MSC in mainstream clinical treatment strategies. It is therefore imperative for the future success of stem cell-based treatment approaches that are more reliable, and accessible sources of MSC are identified. The present chapter describes a method for generating MSC-like cells from induced pluripotent stem cells (iPSC), with equivalent growth and functional properties to parental MSC populations.
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