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Related Concept Videos

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Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
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Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
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Microbial competition is an ecological interaction in which microorganisms vie for limited resources within shared environments. These resources may include nutrients, space, or light, depending on the system. The intensity and outcome of competition are influenced by the environmental context, such as nutrient availability, spatial constraints, and the diversity of microbial species present. These competitive interactions significantly influence the structure, function, and resilience of...
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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Related Experiment Video

Updated: Apr 20, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
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Can chatter between microbes prevent cholera?

Jessica A Thompson1, Rita Almeida Oliveira1, Karina B Xavier2

  • 1Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

Trends in Microbiology
|December 4, 2014
PubMed
Summary
This summary is machine-generated.

New research reveals beneficial gut bacteria can inhibit Vibrio cholerae colonization. This discovery highlights natural microbe-microbe interactions as a potential strategy against infectious diseases and antibiotic resistance.

Keywords:
AI-2LuxSbacterial signallingcell–cell communicationmicrobiotaquorum sensing

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Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Microbiome Research

Background:

  • Antibiotic resistance is a growing global health threat.
  • The human gut microbiome plays a crucial role in health and disease.
  • Understanding microbe-microbe interactions is key to developing new therapeutic strategies.

Purpose of the Study:

  • To identify commensal gut bacteria that antagonize Vibrio cholerae colonization.
  • To explore the mechanisms underlying this antagonistic interaction, potentially involving quorum sensing.

Main Methods:

  • Microbiome analysis to identify potential inhibitory bacteria.
  • In vitro or in vivo models to confirm the inhibitory effects of identified bacteria.
  • Investigating quorum sensing pathways as a potential mechanism.

Main Results:

  • Specific commensal gut bacteria were identified that significantly reduce Vibrio cholerae colonization.
  • Evidence suggests that quorum sensing may mediate this antagonistic interaction.

Conclusions:

  • Commensal gut bacteria possess natural mechanisms to inhibit pathogen colonization.
  • Harnessing these microbe-microbe interactions, potentially via quorum sensing modulation, offers a promising avenue for novel therapies against infectious diseases like cholera.