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Related Concept Videos

Applications Of NMR In Biology01:25

Applications Of NMR In Biology

4.8K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)01:15

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

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Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
873
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

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A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
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Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

8.6K
Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
8.6K

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High-resolution microtesla in-situ<sup>13</sup>C NMR detection of "scaled-up" SABRE-hyperpolarization of [1-<sup>13</sup>C]pyruvate.

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Updated: Apr 20, 2026

Hyperpolarized Xenon for NMR and MRI Applications
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Hyperpolarized Xenon for NMR and MRI Applications

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NMR hyperpolarization techniques for biomedicine.

Panayiotis Nikolaou1, Boyd M Goodson, Eduard Y Chekmenev

  • 1Institute of Imaging Science (VUIIS), Department of Radiology, Department of Biomedical Engineering, Department of Physics and Astronomy and Department of Biochemistry, Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University, 1161 21st Ave South AA-1107, Nashville, Tennessee, 37232-2310 (USA).

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 4, 2014
PubMed
Summary

Nuclear Magnetic Resonance (NMR) hyperpolarization advances enable new in vivo molecular imaging for lung and cancer studies. This article reviews hyperpolarized contrast agent preparation and clinical validation progress.

Keywords:
dynamic nuclear polarizationhyperpolarizationmedicinal chemistrymolecular imagingspin exchange optical pumping

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Area of Science:

  • Medical Imaging
  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Biomedical Engineering

Background:

  • Nuclear Magnetic Resonance (NMR) hyperpolarization has significantly advanced molecular imaging.
  • New imaging modalities offer enhanced functional and metabolic insights.

Purpose of the Study:

  • To explore recent advances in hyperpolarized contrast agent preparation.
  • To review the application of these agents in various in vivo imaging modalities.
  • To discuss the clinical validation status of these novel imaging agents.

Main Methods:

  • Review of recent scientific literature on NMR hyperpolarization techniques.
  • Analysis of methods for preparing and utilizing hyperpolarized contrast agents.
  • Evaluation of current progress towards clinical translation.

Main Results:

  • NMR hyperpolarization facilitates diverse in vivo imaging applications.
  • Applications include functional lung imaging and metabolic cancer imaging.
  • Many hyperpolarized agents are nearing clinical validation.

Conclusions:

  • Hyperpolarized contrast agents represent a significant leap in molecular imaging capabilities.
  • These agents are poised for widespread clinical use in diagnosing and monitoring diseases.
  • Continued research promises further expansion of NMR-based imaging applications.