[Assesment of effectiveness of nucleotide therapy after sciatic nerve injury]

Experimental and clinical data have shown that there is an increase in the necessity of pyrimidine nucleotides after peripheral nerve injury. The aim of the study was to estimate the neuroprotective efficacy of the Nucleo CMP preparation (Nucleo CMP. Ferrer Internacional) containing cytidine monophosphate and uridine triphosphate nucleotides after unilateral compression of the sciatic nerve of rats. We recorded extracellular spike activity of single motoneurons of the spinal cord on the ipsilateral side towards injury during high frequency stimulation of distal collaterals (nervus tibialis and nervus peroneus communis) of the injured sciatic nerve. The degree of the expression and the ratio of excitation/inhibition responses of motoneurons in the Nucleo CMP group are close to the norm. In the Nucleo CMP group on the 30 day it was revealed a restoration of test reflex abduction indices and the static sciatic index of injured lower extremities. A single administration of therapeutic dose of Nucleo CMP in intact rats caused an increase in the background and evoked spike activity of single motoneurons from 10 to 80 minutes.