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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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USP11 regulates p53 stability by deubiquitinating p53.

Jia-ying Ke1, Cong-jie Dai, Wen-lin Wu

  • 1College of Chemistry and Life Science, Quanzhou Normal University, Quanzhou 36200, China; The Higher Educational Key Laboratory for Molecular Biology and Pharmacology of Fujian Province, Quanzhou 36200, China; Xiamen Women and Children Health Hospital, Xiamen 361005, China; Shouguang People's Hospital, Shouguang 262700, China; Department of Orthopedics, Central Hospital of Zibo, Zibo 255000, China; Department of Pathology, University of Chicago, Chicago 60102, Illinois, USA; Department of Pathology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 36200, China.

Journal of Zhejiang University. Science. B
|December 5, 2014
PubMed
Summary

Ubiquitin-specific protease 11 (USP11) stabilizes the p53 tumor suppressor protein by removing ubiquitin tags. USP11 is crucial for activating p53 in response to DNA damage.

Keywords:
DeubiquitinationStabilityUSP11p53

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