Surgical management of necrotizing pancreatitis: an overview

George Kokosis1, Alexander Perez1, Theodore N Pappas1

  • 1George Kokosis, Alexander Perez, Theodore N Pappas, Department of Surgery, Duke University Medical Center, Durham, NC 27705, United States.

Insights

Necrotizing pancreatitis, a severe acute pancreatitis complication, now favors conservative and minimally invasive strategies over open surgery. The "3 Ds" approach—Delay, Drain, and Debride—guides modern management for better patient outcomes.

Area of Science:

  • Gastroenterology
  • Surgical Gastroenterology
  • Critical Care Medicine

Background:

  • Necrotizing pancreatitis is a severe complication of acute pancreatitis, associated with high mortality rates, especially when infected.
  • Historically, open surgical debridement was the primary treatment, but it yielded poor outcomes.

Purpose of the Study:

  • To summarize the contemporary management approach for necrotizing and/or infected pancreatitis.
  • To highlight the shift from open surgery to minimally invasive techniques and conservative strategies.

Main Methods:

  • Review of current management principles for necrotizing pancreatitis.
  • Emphasis on the "3 Ds" approach: Delay, Drain, and Debride.
  • Description of a phased intervention strategy starting with conservative care and progressing to minimally invasive drainage and debridement if necessary.

Main Results:

  • The contemporary approach prioritizes delaying intervention and utilizing percutaneous drainage.
  • Minimally invasive techniques like endoscopic or video-assisted retroperitoneoscopic drainage/necrosectomy are preferred over open surgery.
  • Open surgery is reserved for refractory cases.

Conclusions:

  • Management of necrotizing pancreatitis has evolved towards a multidisciplinary, dynamic model.
  • Minimally invasive approaches and delayed intervention are key to improving outcomes in necrotizing pancreatitis.
  • Necrotizing pancreatitis is best managed as a complex medical condition requiring a team approach, not solely a surgical disease.