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Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain
F Nicoletti1, P L Canonico, A Favit
1Institute of Pharmacology, University of Catania, School of Medicine, Italy.
European Journal of Pharmacology
|January 31, 1989
Abstract:
Stimulation of inositol phospholipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositol monophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.