Related Experiment Video
Updated: Apr 19, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
Circulating miRNAs in cancer: from detection to therapy
1Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou, 510275, P. R. China. wwt0603sky@gmail.com.
Circulating microRNAs (miRNAs) are stable molecules found in body fluids, showing promise as non-invasive cancer biomarkers. This review covers their detection, therapeutic potential, and role in cell communication for cancer management.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation.
- Circulating miRNAs detected in body fluids offer potential as non-invasive biomarkers.
- Extracellular miRNAs play roles in cell-cell communication and tumorigenesis.
Purpose of the Study:
- To review advances in circulating miRNA detection methods.
- To summarize the clinical applications of circulating miRNAs as cancer biomarkers.
- To discuss the therapeutic potential and challenges of circulating miRNAs in oncology.
Main Methods:
- Literature review of studies on circulating miRNAs over the past decade.
- Analysis of various detection methodologies for extracellular miRNAs.
- Evaluation of clinical data on miRNA biomarkers and therapeutic strategies.
Main Results:
- Significant progress in developing sensitive and specific miRNA detection techniques.
- Demonstrated potential of circulating miRNAs for early cancer detection, prognosis, and monitoring.
- Identified roles of miRNAs in tumor microenvironment and intercellular communication.
Conclusions:
- Circulating miRNAs represent a promising frontier for non-invasive cancer diagnostics and therapeutics.
- Further research is needed to overcome limitations in standardization and clinical translation.
- miRNAs hold potential for personalized medicine approaches in cancer care.
More Related Videos
Related Concept Videos
MicroRNAs
MicroRNAs
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
lncRNA - Long Non-coding RNAs

