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Related Experiment Video

Updated: Apr 19, 2026

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
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Modulating functional and dysfunctional mentalizing by transcranial magnetic stimulation.

Tobias Schuwerk1, Berthold Langguth2, Monika Sommer2

  • 1Department of Psychology, Ludwig-Maximilians-University Munich, Germany ; Department of Psychiatry and Psychotherapy, University of Regensburg Regensburg, Germany.

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|December 6, 2014
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Summary

This review explores how transcranial magnetic stimulation (TMS) helps understand the neurocognitive basis of mentalizing and its impairment in psychiatric disorders. It evaluates TMS effectiveness for future research directions in social cognition.

Keywords:
autism spectrum disordersmajor depressive disordermentalizingpsychiatric disorderssocial cognitiontheory of mindtranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Psychiatry

Background:

  • Mentalizing, the capacity to understand mental states, is crucial for social interaction.
  • Neuroscientific and clinical research increasingly link mentalizing deficits to psychiatric disorders.
  • Transcranial magnetic stimulation (TMS) is emerging as a tool in both basic and clinical mentalizing research.

Purpose of the Study:

  • To integrate findings from neuroscientific and clinical applications of TMS in mentalizing research.
  • To provide a detailed picture of the neurocognitive basis of mentalizing and its alterations in psychiatric conditions.
  • To evaluate the effectiveness of current TMS techniques, protocols, and outcome measures.

Main Methods:

  • Systematic review of neuroscientific studies using TMS to modulate mentalizing.
  • Review of clinical studies employing TMS for treating impaired mentalizing in psychiatric disorders.
  • Analysis of stimulation techniques, experimental paradigms, and outcome measures.

Main Results:

  • TMS can modulate mentalizing, aiding the decomposition of its neurocognitive components.
  • Evidence suggests mentalizing is affected across various psychiatric disorders, with TMS showing therapeutic potential.
  • Current TMS protocols vary, necessitating standardized approaches for optimal effectiveness.

Conclusions:

  • Integrating neuroscientific and clinical TMS research offers deeper insights into mentalizing's neurocognitive underpinnings.
  • TMS is a promising tool for both understanding and potentially treating social cognitive deficits in psychiatric populations.
  • Future research should focus on refining TMS protocols and outcome measures for robust findings in social cognition.