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Updated: Apr 19, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Advanced imaging in COPD: insights into pulmonary pathophysiology
Stephen Milne1, Gregory G King1
11 The Woolcock Institute of Medical Research, Glebe, Sydney NSW 2037, Australia ; 2 Northern Clinical School, University of Sydney, NSW 2006, Australia ; 3 Northern and Central Clinical Schools, University of Sydney, NSW 2006, Australia ; 4 Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
Advanced imaging techniques now allow simultaneous assessment of structural and functional abnormalities in chronic obstructive pulmonary disease (COPD). This review covers current and emerging modalities for studying COPD pathophysiology and future applications.
Area of Science:
- Pulmonary Medicine
- Medical Imaging
- Biophysics
Background:
- Chronic obstructive pulmonary disease (COPD) is characterized by complex structural and functional abnormalities.
- Historically, these abnormalities have been studied in isolation, limiting comprehensive understanding.
- Advanced imaging offers a unified approach to studying COPD's multifaceted nature.
Purpose of the Study:
- To provide a comprehensive review of advanced imaging modalities for COPD research.
- To highlight the integration of structural and functional assessments in COPD.
- To discuss the future potential of imaging in clinical and research settings for COPD.
Main Methods:
- Review of established and emerging advanced imaging techniques.
- Inclusion of computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT).
- Description of novel techniques such as micro-CT, synchrotron imaging, optical coherence tomography (OCT), and electrical impedance tomography (EIT).
Main Results:
- Advanced imaging enables simultaneous evaluation of pathological processes and physiological consequences in COPD.
- These techniques provide significant pathophysiological insights into COPD.
- The review details the application and findings from various imaging modalities.
Conclusions:
- Advanced imaging is crucial for a holistic understanding of COPD.
- Future applications in clinical practice and research are promising.
- Integration of imaging data will advance COPD diagnosis and treatment strategies.
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