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Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract
Lieselotte Veryser1, Lien Taevernier1, Nathalie Roche2
1Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Summary
Pellitorine from Anacyclus pyrethrum penetrates human skin, with extracts showing higher absorption than purified forms. This suggests potential medicinal applications for topical products.
Area of Science:
- Pharmacology
- Dermatology
- Phytochemistry
Background:
- Anacyclus pyrethrum (AP) contains N-alkylamides, notably pellitorine.
- AP extracts are used in cosmeceuticals, but transdermal data for pellitorine is lacking.
Purpose of the Study:
- To investigate the skin pharmacokinetics of pellitorine.
- To compare the transdermal penetration of purified pellitorine versus AP extract.
Main Methods:
- Human skin samples were used in a Franz diffusion cell system.
- Purified pellitorine and AP extract were applied topically.
- Skin layers and receptor fluid were analyzed for pellitorine concentration.
Main Results:
- Pellitorine successfully permeated the stratum corneum and deeper skin layers.
- The AP extract exhibited a higher permeability coefficient (2.3 × 10⁻⁴ cm/h) than purified pellitorine (1.1 × 10⁻⁴ cm/h).
Conclusions:
- Pellitorine demonstrates transdermal potential, with AP extract enhancing its skin penetration.
- Detected concentrations suggest both local and systemic effects are possible.
- Products with significant pellitorine concentrations may warrant classification as medicinal products.
