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Continuous -time Fourier Transform

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High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology

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Digital pathology with Fourier ptychography.

Roarke Horstmeyer¹, Xiaoze Ou¹, Guoan Zheng²

¹Department of Electrical Engineering and Bioengineering, California Institute of Technology, Pasadena, CA 91125, United States.

Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society

|December 8, 2014

Summary

Fourier ptychographic microscopy (FPM) enhances histology imaging by improving resolution and capturing phase data. This advanced technique offers wider fields of view and richer information for digital pathology applications.

Keywords:

Computational imaging Digital pathology Microscopy Structured illumination Super-resolution

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Area of Science:

Microscopy and Imaging Technologies
Digital Pathology
Optical Physics

Background:

Fourier ptychographic microscopy (FPM) is an emerging technique for high-resolution imaging.
Conventional microscopy has limitations in resolution and field of view for histology.
Histology slides contain rich information beyond intensity, including phase data.

Purpose of the Study:

To demonstrate how FPM enhances wide field-of-view (FOV) histology imaging.
To show FPM's capability to record optical phase information from samples.
To highlight the potential of FPM-derived phase data for digital pathology.

Main Methods:

Acquisition of low-resolution images under variable-angle illumination.
Application of a novel phase retrieval algorithm to reconstruct high-resolution images.
Analysis of optical phase information captured during the FPM process.

Main Results:

FPM significantly improves the resolution of wide FOV histology images beyond conventional limits.
FPM successfully records the optical phase of thin biological samples.
The captured phase data provides complementary information to intensity images.

Conclusions:

FPM offers enhanced resolution and wider FOV for histology, improving image quality.
The optical phase information obtained via FPM can be digitally extracted for deeper analysis.
FPM has the potential to advance digital pathology by providing more comprehensive slide information.