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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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"Ready, set, go": checkpoint regulation by Cdk1 inhibitory phosphorylation

J O Ayeni1, S D Campbell

  • 1a Department of Biological Sciences ; University of Alberta ; Edmonton , AB , Canada.

Fly
|December 9, 2014
PubMed
Summary

Cell cycle checkpoints use inhibitory phosphorylation of Cdk1 to prevent mitosis. This study reveals complex checkpoint states beyond a simple on/off switch, crucial for DNA repair and cell cycle regulation.

Keywords:
cell cycle checkpoint, Cdk1 inhibitory phosphorylation, mitosis, genome stability

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