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Long non-coding RNAs as emerging regulators of differentiation, development, and disease
Bijan K Dey1, Adam C Mueller, Anindya Dutta
1a Department of Biochemistry and Molecular Genetics ; University of Virginia School of Medicine ; Charlottesville , VA USA.
Transcription
|December 9, 2014
Summary
Long non-coding RNAs (lncRNAs), once thought to be transcriptional noise, are now recognized as crucial regulators in cellular processes. This review details their roles in differentiation, development, and disease.
Area of Science:
- Genomics
- Molecular Biology
- RNA Biology
Background:
- Mammalian genomes encode numerous long non-coding RNAs (lncRNAs) previously dismissed as transcriptional noise.
- Recent advancements reveal lncRNAs possess significant regulatory functions in biological systems.
Purpose of the Study:
- To review the current understanding of lncRNA-mediated regulation.
- To highlight the critical roles of lncRNAs in cellular differentiation, development, and disease.
Main Methods:
- Literature review of recent studies on lncRNA function and regulation.
- Synthesis of findings on lncRNA roles in key biological processes.
Main Results:
- lncRNAs are integral to cellular differentiation pathways.
- lncRNAs significantly influence organismal development.
- Dysregulation of lncRNAs is implicated in various diseases.
Conclusions:
- lncRNAs are essential regulators of fundamental cellular processes.
- Further research into lncRNAs holds promise for understanding and treating diseases.
Keywords:
Bvht, braveheartCDT, C-terminal domainDBE-T, D4Z4-binding elementDMD, Duchenne muscular dystrophyES, embryonic stemFSHD, facioscapulohumeral muscular dystrophyFendrr, Foxf1a called fetal-lethal non-coding developmental regulatory RNAMEF2, myocyte enhancer factor-2MRFs, myogenic regulatory factorsMalat1, metastasis associated lung adenocarcinoma transcript 1Mesp1, mesoderm progenitor 1Neat2, nuclear-enriched abundant transcript 2PRC2, polycomb group repressive complex 2RNAP II, RNA polymerase IISINE, short interspersed elementSR, serine arginineSRA, steroid receptor activatorSRY, sex-determining region YYAM 1-4, YY1-associated muscle 1-4ceRNAs, competing endogenous RNAsciRS-7, circular RNA sponge for miR-7developmentdifferentiationdiseasegene expressioniPS, induced pluripotent stemlncRNAs, long non-coding RNAslong non-coding RNAsncRNAa, non-coding RNA activatingskeletal muscle
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