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Updated: Apr 19, 2026

Author Spotlight: Hypothalamic Neural Mechanism Insights
Published on: August 4, 2023
Interactions of the orexin/hypocretin neurones and the histaminergic system
1Institute of Biomedicine, Anatomy, and Neuroscience center, University of Helsinki, Helsinki, Finland.
Abstract:
Histaminergic and orexin/hypocretin systems are components in the brain wake-promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurones are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurones is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models.
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