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Updated: Apr 19, 2026

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities
Published on: October 27, 2023
Multimodal Image Reconstruction Using Supplementary Structural Information in Total Variation Regularization
Daniil Kazantsev1, William R B Lionheart2, Philip J Withers1
1The Manchester X-ray Imaging Facility, School of Materials, The University of Manchester, Manchester, M13 9PL UK ; The Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA UK.
Abstract:
In this paper, we propose an iterative reconstruction algorithm which uses available information from one dataset collected using one modality to increase the resolution and signal-to-noise ratio of one collected by another modality. The method operates on the structural information only which increases its suitability across various applications. Consequently, the main aim of this method is to exploit available supplementary data within the regularization framework. The source of primary and supplementary datasets can be acquired using complementary imaging modes where different types of information are obtained (e.g. in medical imaging: anatomical and functional). It is shown by extracting structural information from the supplementary image (direction of level sets) one can enhance the resolution of the other image. Notably, the method enhances edges that are common to both images while not suppressing features that show high contrast in the primary image alone. In our iterative algorithm we use available structural information within a modified total variation penalty term. We provide numerical experiments to show the advantages and feasibility of the proposed technique in comparison to other methods.
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