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Updated: Apr 19, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Crystal structure of N-(quinolin-6-yl)hydroxyl-amine
Anuruddha Rajapakse1, Roman Hillebrand1, Sarah M Lewis1
1125 Chemistry Bldg, University of Missouri Columbia, MO 65211, USA.
Abstract:
The title compound, C9H8N2O, crystallized with four independent mol-ecules in the asymmetric unit. The four mol-ecules are linked via one O-H⋯N and two N-H⋯N hydrogen bonds, forming a tetra-mer-like unit. In the crystal, mol-ecules are further linked by O-H⋯N and N-H⋯O hydrogen bonds forming layers parallel to (001). These layers are linked via C-H⋯O hydrogen bonds and a number of weak C-H⋯π inter-actions, forming a three-dimensional structure. The crystal was refined as a non-merohedral twin with a minor twin component of 0.319.
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