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Updated: Apr 19, 2026

Dissecting Cell-Autonomous Function of Fragile X Mental Retardation Protein in an Auditory Circuit by In Ovo Electroporation
Published on: July 6, 2022
Cognitive aspects of Fragile X syndrome
Lillie B Huddleston1, Jeannie Visootsak1, Stephanie L Sherman1
1Department of Human Genetics, Emory University, Decatur, GA, USA.
Abstract:
Fragile X syndrome (FXS) is the leading inherited cause of intellectual disability. It is primarily caused by the expansion of a CGG trinucleodide repeat located in the 5' untranslated region of the X-linked FMR1 gene. Individuals with FXS present with variable intellectual quotients (IQs) ranging from the average to the severe intellectual disability level. A range of neurocognitive strengths and challenges are observed in individuals with FXS. This article provides an overview of our current understanding related to cognition and FXS. Cognitive functioning levels, profiles, and IQ trajectories are discussed. Limitations of existing neuropsychological measures are described. WIREs Cogn Sci 2014, 5:501-508. doi: 10.1002/wcs.1296 This article is categorized under: Neuroscience > Cognition.
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