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Related Experiment Video

Updated: Apr 19, 2026

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

Published on: August 31, 2017

Viruses and viral proteins.

Nuria Verdaguer¹, Diego Ferrero¹, Mathur R N Murthy²

¹Institut de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Baldiri i Reixac 15, 08028-Barcelona, Spain.

|December 9, 2014

Summary

This summary is machine-generated.

X-ray crystallography has been crucial for understanding virus structures and functions for over 30 years. This technique reveals viral life cycle details, aiding in the development of antiviral drugs against human pathogens.

Keywords:

RNA-dependent RNA polymerases bacteriophages fusion proteins genome delivery viral proteases viral receptors viruses

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Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

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Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

Published on: December 21, 2019

Area of Science:

Structural biology
Virology
Drug discovery

Background:

X-ray crystallography is the leading method for atomic-resolution virus structure determination.
Viral structures provide insights into critical life cycle stages like entry and replication.
Many determined viral structures represent potential antiviral drug targets.

Purpose of the Study:

To provide an overview of structural knowledge regarding viral life cycle processes.
To highlight the significance of X-ray crystallography in virology.
To connect structural information to antiviral drug development.

Main Methods:

X-ray crystallography for atomic-resolution structure determination.
Analysis of viral protein and complex structures.
Review of existing literature on viral structures and functions.

Main Results:

Detailed structural insights into viral cell-receptor recognition.
Structural understanding of viral entry mechanisms.
Structural basis for nucleic acid transfer and genome replication elucidated.
Identification of numerous viral structures as potential antiviral targets.

Conclusions:

X-ray crystallography has profoundly advanced our understanding of viruses.
Structural data is essential for comprehending viral pathogenesis and life cycles.
Knowledge of viral structures is key to developing effective antiviral therapies.