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Updated: Apr 19, 2026

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking

M Z Ratajczak1

  • 1Stem Cell Biology Program, Stella and Henry Hoenig Endowed Chair, Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

Leukemia
|December 10, 2014
PubMed

This review presents a novel view and working hypothesis about the hierarchy within the adult bone marrow stem cell compartment and the still-intriguing question of whether adult bone marrow contains primitive stem cells from early embryonic development, such as cells derived from the epiblast, migrating primordial germ cells or yolk sac-derived hemangioblasts. It also presents a novel view of the mechanisms that govern stem cell mobilization and homing, with special emphasis on the role of the complement cascade as a trigger for egress of hematopoietic stem cells from bone marrow into blood as well as the emerging role of novel homing factors and priming mechanisms that support stromal-derived factor 1-mediated homing of hematopoietic stem/progenitor cells after transplantation.

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