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Updated: Apr 19, 2026
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Published on: March 24, 2023
Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant
Shizuo Kayama1, Norifumi Shigemoto2, Ryuichi Kuwahara3
1Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima City, Hiroshima, Japan Department of Bacteriology, Hiroshima University Graduate School of Biomedical Health Sciences, Hiroshima City, Hiroshima, Japan.
Abstract:
We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.
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