Related Experiment Video
Updated: Apr 19, 2026
11:12
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
Published on: October 17, 2013
14.3K
Emerging trends in heart valve engineering: Part I. Solutions for future
Arash Kheradvar1, Elliott M Groves, Lakshmi P Dasi
1Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA, arashkh@uci.edu.
Annals of Biomedical Engineering
|December 10, 2014
Summary
This review covers new heart valve replacement research, including tissue-engineered valves and permanent polymeric options. Understanding cellular responses is key for future regenerative therapies.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Cardiovascular Engineering
Background:
- Current heart valve replacement options have limitations.
- Novel materials and techniques are needed for improved patient outcomes.
Purpose of the Study:
- To provide an overview of novel heart valve replacement research.
- To discuss tissue-engineered and polymeric heart valves.
- To highlight the importance of cellular microenvironment sensing in tissue engineering.
Main Methods:
- Review of current research and development in heart valve fabrication.
- Discussion of in vitro and in vivo tissue-engineered heart valves.
- Analysis of polymeric materials for permanent heart valve prostheses.
Main Results:
- Polymeric heart valves offer cost-effective, manufacturable, and integrable solutions for adults.
- Tissue-engineered heart valves represent a promising regenerative, patient-specific future.
- Cellular response to microenvironmental stimuli is critical for tissue-engineered valve development.
Conclusions:
- Novel heart valve replacements are advancing beyond current standards.
- Both polymeric and tissue-engineered approaches present distinct advantages.
- Further research into cellular mechanisms is essential for optimizing regenerative valve therapies.
More Related Videos
Related Concept Videos
01:16Heart Valves
16.9K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
16.9K
01:25Aortic Regurgitation III: Medical Management
562
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
562
01:26Mitral Stenosis III: Medical Management
490
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
490
01:25Mitral Regurgitation III: Medical Management
631
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
631
01:22Mitral Valve Prolapse II: Assessment and Management
1.3K
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
1.3K