A hospital based study on reference range of serum prostate specific antigen levels

Area of Science:

• Urology
• Biochemistry
• Public Health

Background:

• Serum prostate specific antigen (PSA) levels are influenced by various factors including race, ethnicity, environment, lifestyle, and age.
• Existing PSA reference ranges may not be universally applicable across diverse global populations.
• Understanding age-specific PSA variations is crucial for accurate interpretation of screening tests.

Purpose of the Study:

• To determine the age-specific reference range of serum PSA in healthy Indian men.
• To compare these findings with PSA levels reported in international populations.

Main Methods:

• Analysis of serum PSA values from 1253 healthy adult Indian men aged 40 and above.
• Participants were recruited from an Executive Health Check-up program in Haryana, India.
• Men with urological conditions that could affect PSA were excluded.

Main Results:

• Established age-specific serum PSA reference ranges for Indian men.
• PSA levels showed a clear association with increasing age across all studied groups.
• Specific ranges: <40 yr (0.71 ng/ml), 40-49 yr (0.85 ng/ml), 50-59 yr (1.13 ng/ml), 60-69 yr (1.45 ng/ml), 70-79 yr (1.84 ng/ml), >80 yr (2.35 ng/ml).

Conclusions:

• The study provides essential age-specific serum PSA reference ranges for healthy Indian men.
• Findings highlight the importance of age-adjusted PSA interpretation in clinical practice.
• This data contributes to a better understanding of PSA variations in different ethnic groups.