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Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide
1Department of Radiology, Duke University Medical Center, Durham, NC 27701.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|January 1, 1989
Abstract:
Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.