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An improved efficient synthesis of the antibacterial agent torezolid
Gang Li1, Bao-Kun Yuan, Wu Tang
1State Key Laboratory of Bioactive Substances and Function of Natural Medicine and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences.
Chemical & Pharmaceutical Bulletin
|December 11, 2014
Abstract:
An improved and efficient method for the preparation of torezolid based on Suzuki cross-coupling reaction as the key step was developed on a gram scale in five steps. The total yield was 44% and the optical purity of torezolid by the improved method was above 99%.

