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Updated: Apr 19, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
[A cross-sectional and factor analysis study on HIV, HBV and HIV/HBV infection in a Yi Prefecture, southwest China]
Yan Shi1, Yibiao Zhou1, Shijiao Nie1
1Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology School of Public Health, Fudan University, Shanghai 200032, China.
Objective:
To understand the epidemiological characteristics and related risk factors on HIV, HBV infection of people from the southwest province of China and to provide basic data for the development of related strategies.
Methods:
According to the information on current HIV epidemics, one township from the area was selected as the study field and all the adult population were surveyed using a questionnaire to collect social demographic data and information on infection-related factors.
Results:
A total of 2 290 adults were investigated and data showed as follows:the average HIV infection rate as 7.9% , the average HBV infection rate as 3.1%, and the average HIV/HBV co-infection rate as 1.2%. As for HIV infection, people whose yearly family gross income between 1 000 and 3 000 Yuan (OR = 0.28) or more than 5 000 Yuan (OR = 0.14) were less likely to be infected with HIV than those people whose annual family gross income less than 1 000 Yuan. People with educational level of primary school and above were more likely to carry HIV than those who were illiterate (OR = 3.28). People who had the history of migration were less likely to carry HIV than those who had not (OR = 0.33). People who had the history of being drug abusers were more likely to infect HIV than those who had not (OR = 46.32). People whose spouses had the history of using drugs were more likely to infect HIV than those who had not (OR = 3.52). People whose spouses had been infected with HIV were more likely to infect HIV than those who had not (OR = 9.56). As for HBV infection, people who had the history of migration were more likely to infect HBV(OR = 2.48). As for HIV/HBV co-infection, people whose spouses had the history of HIV infection were more likely to infect HIV/HBV co-infection than others who did not have the history (OR = 6.04).
Conclusion:
There had been a serious HIV/AIDS epidemic in our study field. Other than taking measures as detection and vaccination on HBV, health education should be strengthened, together with measurements as needle exchange and methadone substitution therapy, to control the spread of AIDS.
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