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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Dual-cargo selectively controlled release based on a pH-responsive mesoporous silica system.

Wanyuan Gui1, Wenqian Wang, Xiangyu Jiao

  • 1Department of Chemistry & Biological Engineering, University of Science and Technology Beijing, 100083 Beijing, (China).

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
|December 11, 2014
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Summary

This study presents pH-controlled mesoporous silica nanoparticles (MSNs) for selective dual-cargo release. Different cargoes are released at distinct pH levels, advancing nanomedicine delivery systems.

Keywords:
drug deliverymesoporous materialsnanostructuressensorssol-gel processes

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Mesoporous silica nanoparticles (MSNs) offer versatile platforms for drug delivery.
  • Achieving controlled and selective cargo release remains a challenge in nanomedicine.
  • Current delivery systems often lack specificity in cargo release based on environmental stimuli.

Purpose of the Study:

  • To develop a pH-controlled dual-cargo delivery system using mesoporous silica nanoparticles.
  • To engineer MSNs with tunable particle and pore sizes for enhanced release control.
  • To demonstrate selective release of different cargoes at distinct pH values.

Main Methods:

  • Fabrication of MSNs using a modified sol-gel method for precise size control.
  • Loading of two distinct cargoes into the MSNs.
  • Testing the pH-responsive release profiles at pH 2.0 and pH 7.0.

Main Results:

  • MSNs with tunable particle and pore sizes were successfully synthesized.
  • Selective release of one cargo was observed at pH 2.0.
  • Selective release of the second cargo was observed at pH 7.0.
  • The system demonstrated distinct cargo release based on pH stimuli.

Conclusions:

  • A novel pH-controlled dual-cargo delivery system based on MSNs was successfully developed.
  • The system enables selective release of different cargoes at specific pH values.
  • This advancement holds significant promise for targeted drug delivery and nanomedicine applications.