Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Simultaneous T<sub>2</sub>, T<sub>2</sub>*, and R<sub>2</sub>' Mapping for Multiple Sclerosis Using Nonlinear Model-Based Reconstruction of Undersampled Radial RARE-EPI MRI.

Magnetic resonance in medicine·2026

Same author

Annual report of the presidents of the AACN, ABCN, and AACNF.

The Clinical neuropsychologist·2026

Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

Mapping cellular targets of covalent cancer drugs in the entire mammalian body.

Cell·2025

Same author

A generalizable 3D framework and model for self-supervised learning in medical imaging.

NPJ digital medicine·2025

Same author

Mapping cellular targets of covalent cancer drugs in the entire mammalian body.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

Concussive brain injury from explosive blast.

Nihal C de Lanerolle¹, Hamada Hamid², Joseph Kulas³

¹Department of Neurosurgery, Yale University New Haven, Connecticut, 06520.

Annals of Clinical and Translational Neurology

|December 11, 2014

Summary

This summary is machine-generated.

Magnetic resonance spectroscopic imaging (MRSI) detects hippocampal injury in veterans with explosive blast mild traumatic brain injury (mTBI). This brain injury is linked to memory deficits and differs from posttraumatic stress disorder (PTSD) injury.

More Related Videos

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Published on: November 6, 2020

Author Spotlight: Developing Precise and Clinically Relevant Models for Studying Secondary Degeneration in Traumatic Optic Neuropathy

Author Spotlight: Developing Precise and Clinically Relevant Models for Studying Secondary Degeneration in Traumatic Optic Neuropathy

Published on: November 29, 2024

Related Experiment Videos

Last Updated: Apr 19, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Published on: November 6, 2020

Author Spotlight: Developing Precise and Clinically Relevant Models for Studying Secondary Degeneration in Traumatic Optic Neuropathy

Author Spotlight: Developing Precise and Clinically Relevant Models for Studying Secondary Degeneration in Traumatic Optic Neuropathy

Published on: November 29, 2024

Area of Science:

Neuroscience
Radiology
Military Medicine

Background:

Explosive blast mild traumatic brain injury (mTBI) causes memory impairment and posttraumatic stress disorder (PTSD).
Hippocampal injury is a known consequence of explosive shock waves.
Magnetic resonance spectroscopic imaging (MRSI) shows promise for detecting mTBI-related brain injury.

Purpose of the Study:

To apply MRSI to study veterans with explosive blast mTBI.
To compare hippocampal injury in veterans with mTBI, controls, and subjects with PTSD without blast exposure.
To correlate MRSI findings with neuropsychiatric and cognitive deficits.

Main Methods:

MRSI at 7 Tesla was used to study the hippocampi of 25 veterans with blast mTBI, 20 controls, and 12 subjects with PTSD (no blast).
Psychiatric and cognitive assessments were performed.
MRSI data were analyzed for metabolite ratios (NAA/Ch, NAA/Cr) and hippocampal volume.

Main Results:

Veterans with blast mTBI showed reduced N-acetyl aspartate to choline (NAA/Ch) and N-acetyl aspartate to creatine (NAA/Cr) ratios in the anterior hippocampus (P < 0.05).
The right hippocampus was 15% smaller in volume in the mTBI group (P < 0.05).
These changes were independent of PTSD, depression, or anxiety comorbidities. PTSD without blast showed lesser, posterior hippocampal injury and less visual memory reduction.

Conclusions:

Hippocampal injury location differentiates explosive blast mTBI from PTSD.
MRSI effectively detects and localizes neuronal injury in the hippocampus associated with memory impairment following blast exposure.