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Updated: Apr 19, 2026
07:03
Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
Published on: October 2, 2020
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CD44: A key player in breast cancer.
1School of Biotechnology, International Institute of Information Technology, Pune, India.
Indian Journal of Cancer
|December 11, 2014
Summary
CD44, a key receptor, is upregulated in breast cancer, promoting tumor growth and metastasis. Targeting CD44 offers a promising therapeutic strategy for breast cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- CD44 is a transmembrane receptor crucial for linking the extracellular matrix to the cytoskeleton.
- Upregulation of CD44 is observed in breast cancer, correlating with tumor progression and metastasis.
- The CD44+/CD24- cell population is identified as a marker for breast cancer stem cells.
Purpose of the Study:
- To review the role of CD44 in breast cancer.
- To explore CD44 as a potential therapeutic target for breast cancer treatment.
Main Methods:
- Literature search using databases such as PubMed and BMC Cancer.
- Analysis of clinical and experimental findings related to CD44 function in cancer.
Main Results:
- CD44 is implicated in tumor proliferation, invasion, and migration in breast cancer.
- CD44 plays a role in pathways essential for cancer cell survival.
- CD44 expression levels correlate with patient survival outcomes.
Conclusions:
- CD44's multifaceted role in breast cancer progression and stem cell maintenance highlights its significance.
- CD44 represents a promising therapeutic target for improving breast cancer treatment strategies.
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