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Noninvasive approaches for detecting and monitoring bladder cancer

Sarmistha Talukdar1, Luni Emdad, Swadesh K Das

  • 1Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA.

Expert Review of Anticancer Therapy
|December 11, 2014
PubMed

Insights

Early detection of bladder cancer through genetic biomarkers in blood or urine can improve patient survival rates. This review explores noninvasive methods for monitoring bladder cancer progression and prognosis.

Area of Science:

  • Oncology
  • Urology
  • Genetics

Background:

  • Bladder cancer is a prevalent urinary tract malignancy.
  • Deeply invasive bladder cancers have a poor prognosis (30-50% survival).
  • Current treatments include surgery, chemotherapy, and radiotherapy.

Purpose of the Study:

  • To review the efficacy of genetic biomarkers for bladder cancer detection.
  • To highlight potential prognostic markers for noninvasive monitoring.
  • To discuss the role of biomarkers in improving patient outcomes.

Main Methods:

  • Literature review of studies on bladder cancer biomarkers.
  • Analysis of nuclear and mitochondrial biomarkers.
  • Evaluation of biomarkers in blood, plasma, serum, and urine samples.

Main Results:

  • Genetic factors significantly contribute to bladder cancer progression.
  • Biomarkers found in bodily fluids offer potential for early detection.
  • Several molecules show promise as prognostic indicators.

Conclusions:

  • Noninvasive detection of bladder cancer through biomarkers is crucial.
  • Biomarker analysis can aid in surveillance and monitoring.
  • Further research into prognostic markers can improve bladder cancer management.
Keywords:
biomarkerbladder cancernoninvasive detection

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