[Protective effect of nedocromil on hypo- and hypertonic solution-induced airway obstruction in exogenous allergic...

Nedocromil is a new non-bronchodilator substance with mast cell stabilizing properties. In an acute placebo-controlled randomized double blind study, the protective effect of nedocromil on the bronchoconstrictor action of nebulised hypo-(distilled water) and hyperosmolar (4% saline) solutions was investigated in 12 patients with allergic asthma. Inhalations of distilled water and hypertonic saline had similar bronchoconstrictor effects. The effect of both solutions was significantly (p less than 0.01) attenuated by pretreatment with nedocromil, as compared with placebo. Thus, nedocromil could be useful in the treatment of allergic asthma.