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Interleukin-23 receptor genetic polymorphisms and ulcerative colitis susceptibility: A meta-analysis
Min Liu1, Wenqian Zhu1, Jun Wang1
1Department of Gastroenterology, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, PR China.
Clinics and Research in Hepatology and Gastroenterology
|December 16, 2014
Summary
This meta-analysis found that certain interleukin-23 receptor (IL-23R) gene polymorphisms are associated with ulcerative colitis (UC) risk. Specifically, rs11209026 and rs7517847 may protect Caucasians, while rs1088967 may protect Asians.
Area of Science:
- Genetics
- Immunology
- Gastroenterology
Background:
- The interleukin-23 receptor (IL-23R) gene is a potential factor in ulcerative colitis (UC) susceptibility.
- Previous studies on IL-23R polymorphisms and UC risk have yielded inconclusive results.
Purpose of the Study:
- To evaluate the association between IL-23R gene polymorphisms and susceptibility to ulcerative colitis (UC).
Main Methods:
- A comprehensive literature search was conducted across multiple databases up to June 2014.
- Meta-analysis of eligible case-control studies was performed for eight IL-23R polymorphisms.
- Statistical analysis was performed using RevMan 5.2 and STATA 12.0.
Main Results:
- Sixteen studies involving 5438 cases and 7380 controls were analyzed.
- SNPs rs11209026, rs7517847, and rs11209032 showed associations with UC risk.
- Stratification by ethnicity revealed protective effects of rs11209026 and rs7517847 in Caucasians, increased risk with rs11209032 in Caucasians, and protection with rs1088967 in Asians.
Conclusions:
- IL-23R polymorphisms rs11209026 and rs7517847 appear protective against UC in Caucasians.
- IL-23R polymorphism rs11209032 may increase UC risk in Caucasians.
- IL-23R polymorphism rs1088967 may be protective against UC in Asians. Further research is needed to clarify these roles.
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