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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
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Multivalent glycocyclopeptides: toward nano-sized glycostructures
Gour Chand Daskhan1, Nathalie Berthet1, Baptiste Thomas1
1Univ. Grenoble Alpes, DCM, 38000 Grenoble, France; CNRS, DCM, 38000 Grenoble, France.
Carbohydrate Research
|December 16, 2014
Summary
Cyclopeptides offer a novel scaffold for presenting carbohydrates multivalently. Recent advances focus on their synthesis and diverse biological applications, from small glycoclusters to large glycodendrimers.
Area of Science:
- Carbohydrate Chemistry
- Medicinal Chemistry
- Supramolecular Chemistry
Background:
- Cyclopeptides are increasingly utilized as scaffolds for multivalent carbohydrate presentation.
- They provide a constrained spatial orientation for precise molecular arrangement.
Purpose of the Study:
- To review recent advancements in the synthesis of cyclopeptide-based carbohydrate structures.
- To highlight the biological applications of these glycoconjugates.
Main Methods:
- Review of literature on cyclopeptide synthesis.
- Analysis of studies on carbohydrate conjugation to cyclopeptide scaffolds.
- Examination of biological data for glycoclusters and glycodendrimers.
Main Results:
- Cyclopeptides enable controlled multivalent display of carbohydrates.
- Synthetic strategies have advanced for creating complex glycopeptide structures.
- Applications span diagnostics, therapeutics, and biomaterials.
Conclusions:
- Cyclopeptide scaffolds offer a versatile platform for advanced glycoconjugate design.
- Continued research promises novel applications in medicine and materials science.
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