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Promiscuity and diversity in 3-ketosteroid reductases

Trevor M Penning1, Mo Chen1, Yi Jin1

  • 1Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

The Journal of Steroid Biochemistry and Molecular Biology
|December 16, 2014
PubMed
Summary

Aldo-keto reductases (AKR1C1-AKR1C4) metabolize steroid hormones through sequential reduction. These enzymes are crucial for regulating steroid hormone levels and impact the efficacy of various synthetic steroid drugs.

Keywords:
AllopregnanoloneNorethynodrelSteroid conjugatesSteroid hormonesTibolone

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