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Comparison of Remimazolam-Flumazenil versus Propofol for Rigid Bronchoscopy: A Prospective Randomized Controlled
Yafei Pan1, Mo Chen2, Fulei Gu3
1Department of Anesthesiology, Zhejiang Cancer Hospital, Research Center for Neuro-Oncology Interaction, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China.
Journal of Clinical Medicine
|January 8, 2023
Summary
Remimazolam-flumazenil offers faster anesthesia recovery than propofol for rigid bronchoscopy patients. This novel sedative allows quicker patient recovery without compromising safety or hemodynamic stability.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Remimazolam is a novel, ultrashort-acting intravenous benzodiazepine sedative-hypnotic.
- It is known to reduce sedation onset and recovery times.
Purpose of the Study:
- To compare the recovery time from general anesthesia between remimazolam-flumazenil and propofol.
- To evaluate safety and hemodynamic stability during rigid bronchoscopy.
Main Methods:
- A randomized trial comparing remimazolam (Group R) and propofol (Group P) in patients undergoing endotracheal surgery.
- Primary outcome: recovery time from general anesthesia. Secondary outcomes: time to loss of consciousness, hemodynamic fluctuations, and adverse events.
Main Results:
- Significantly shorter recovery time in the remimazolam group (140 ± 52 s) compared to the propofol group (374 ± 195 s) (p < 0.001).
- No significant differences in time to loss of consciousness, hemodynamic fluctuations, or adverse events between groups.
Conclusions:
- Remimazolam-flumazenil facilitates faster anesthesia recovery in rigid bronchoscopy compared to propofol.
- Remimazolam-flumazenil provides a safe alternative with comparable hemodynamic stability and adverse event profiles.
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