Prostate histoscanning true targeting guided prostate biopsy: initial clinical experience

Area of Science:

• Urology
• Medical Imaging
• Oncology

Background:

• Prostate biopsies are crucial for diagnosing prostate cancer.
• Current biopsy techniques may have limitations in accurately targeting cancerous lesions.

Purpose of the Study:

• To assess the feasibility of prostate histoscanning true targeting (PHS-TT) for guiding transrectal ultrasound (TRUS) biopsies.
• To evaluate the effectiveness of PHS-TT in improving prostate cancer detection.

Main Methods:

• A prospective, single-center pilot study involving 43 patients undergoing prostate biopsy.
• Prostate histoscanning (PHS) was used to map abnormal areas (≥0.2 cm³).
• TRUS-guided biopsies targeted these areas using specialized software, alongside standard systematic biopsies.

Main Results:

• The mean volume of abnormal areas detected by PHS was 4.3 cm³.
• The overall cancer detection rate was 46.5%.
• PHS-TT cores showed a significantly higher percentage of cancer per core length (55.4% vs. 37.5%) and higher cancer detection in biopsy-naïve patients compared to systematic cores.

Conclusions:

• Prostate histoscanning true targeting (PHS-TT) is a feasible technique for prostate biopsies.
• PHS-TT can serve as an effective tool for real-time guidance during prostate biopsies.
• The technique shows potential for enhancing diagnostic accuracy, particularly in biopsy-naïve individuals.