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Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Updated: Apr 19, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein structure annotation resources.

Margaret J Gabanyi¹, Helen M Berman

¹Center for Integrative Proteomics Research, Rutgers, The State University of New Jersey, 174 Frelinghuysen Road, Piscataway, NJ, 08854, USA, gabanyi@rcsb.rutgers.edu.

Methods in Molecular Biology (Clifton, N.J.)

|December 16, 2014

Summary

This summary is machine-generated.

Protein structure annotation databases provide crucial information for understanding protein function. This review covers key databases and data types for exploring 3-D protein structures.

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A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Area of Science:

Biochemistry and Structural Biology
Bioinformatics and Computational Biology

Background:

Three-dimensional (3-D) protein structures are essential for understanding molecular function.
Protein structure annotation databases curate vital information on experimental 3-D protein structures.

Purpose of the Study:

To introduce primary structure repositories and value-added structural annotation databases.
To describe the range of information provided by these databases.
To explain different levels of annotation data (primary, derived, inferred) and their interpretation.

Main Methods:

Review of existing protein structure repositories and annotation databases.
Analysis of the types of information curated within these databases.
Categorization of annotation data based on origin (primary, derived, inferred).

Main Results:

Identification of key databases for accessing 3-D protein structure information.
Overview of the diverse data types available for structural annotation.
Framework for distinguishing and utilizing different levels of annotation data.

Conclusions:

Protein structure annotation databases are critical resources for molecular biology research.
Understanding annotation data levels ensures accurate interpretation of protein structure-function relationships.
This review provides a guide to navigating and utilizing structural annotation resources effectively.