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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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PiMS: a data management system for structural proteomics.

Chris Morris1

  • 1STFC, Daresbury Laboratory, Sci-Tech Daresbury, Keckwick Lane, Daresbury, Warrington, WA4 4AD, UK, chris.morris@stfc.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)
|December 16, 2014
PubMed
Summary
This summary is machine-generated.

Protein Information Management System (PiMS) is a specialized LIMS for protein scientists, streamlining recombinant protein production data management. This system supports structural and functional applications, from target selection to soluble protein samples.

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Laboratory Informatics

Background:

  • Protein production for structural and functional studies requires robust data management.
  • Existing laboratory information management systems (LIMS) may not be tailored to the specific needs of protein science.
  • Tracking samples and experimental details is crucial for reproducibility and success in protein research.

Purpose of the Study:

  • To introduce the Protein Information Management System (PiMS) as a dedicated LIMS for protein scientists.
  • To highlight PiMS's capabilities in managing data throughout the recombinant protein production workflow.
  • To present the xtalPIMS extension for enhanced support of crystallogenesis and related techniques.

Main Methods:

  • PiMS is a configurable LIMS designed for protein production.
  • It records data from initial target selection through to the final soluble protein sample.
  • The system allows for custom protocol definition to match laboratory-specific working methods.
  • The xtalPIMS extension specifically supports crystallogenesis, crystal fishing, and crystal treatment.

Main Results:

  • PiMS provides a unified and extensible software solution for protein science data management.
  • The xtalPIMS extension enhances capabilities for crystallization experiments.
  • PiMS is configurable to adapt to diverse research methodologies.
  • The system facilitates data entry, sample tracking, and results reporting.

Conclusions:

  • PiMS serves as a comprehensive LIMS tailored for protein production workflows.
  • Its extensibility and configurability make it a versatile tool for protein scientists.
  • The ongoing development aims to establish PiMS as a laboratory standard for protein-related data management.
  • PiMS is freely available to academic users through the Science and Technology Facilities Council (STFC).