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Updated: Apr 19, 2026

Monitoring Stub1-Mediated Pexophagy
Published on: May 12, 2023
Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative
L Margarucci1, M C Monti, A Tosco
1Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano, Salerno, Italy. mcmonti@unisa.it casapullo@unisa.it.
Abstract:
Peroxiredoxin-1, a key enzyme in the cellular detoxification pathway, has been identified through a chemoproteomic approach as the main partner of theonellasterone, a marine bioactive metabolite. A combination of chemical and biochemical assays disclosed its mechanism of action at the molecular level.
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