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Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
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Related Experiment Video

Updated: Apr 19, 2026

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
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Computer simulations of the mouse spermatogenic cycle.

Debjit Ray1, Philip B Pitts2, Cathryn A Hogarth3

  • 1School of Molecular Biosciences, Washington State University, PO Box 647520, Pullman, WA 99164, USA Biological Systems Engineering, Washington State University, Pullman, WA 99164, USA.

Biology Open
|December 16, 2014
PubMed
Summary

This study introduces a novel agent-based model to simulate the mouse spermatogenic cycle, offering insights into male fertility and sperm production dynamics. The model visualizes germ cell development, aiding research in infertility and contraception.

Keywords:
Agent-based modelGerm cellMouseSimulationSpermatogenesisSpermatogenic cycle

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Area of Science:

  • Reproductive Biology
  • Computational Biology
  • Cell Biology

Background:

  • The spermatogenic cycle is crucial for male fertility, involving complex germ and somatic cell interactions.
  • Experimental challenges hinder dynamic visualization and understanding of germ cell roles in testicular morphology.
  • Clinical relevance for male fertility and contraception necessitates better models of sperm production.

Purpose of the Study:

  • To develop an agent-based model simulating the mouse spermatogenic cycle.
  • To provide mechanistic understanding of testicular morphology and sperm production.
  • To create an in silico tool for infertility treatment and contraceptive development.

Main Methods:

  • An agent-based model simulating the mouse spermatogenic cycle over extended time scales.
  • Incorporation of feedback regulation, cell division, differentiation, apoptosis, and movement.
  • Visualization of germ cell dynamics through time-lapse movie format.

Main Results:

  • The model successfully elaborates germ cell dynamics and individual cell behavior.
  • Mechanistic insights into the achievement of testicular morphology and sperm production.
  • Prediction of causal events for altered germ cell arrangements under perturbations.

Conclusions:

  • The agent-based model offers a powerful in silico platform for studying male reproductive processes.
  • Facilitates understanding of male fertility fundamentals and identifies potential therapeutic targets.
  • Serves as an interactive tool for long-term simulation and development of infertility treatments and contraceptives.