Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

856
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
856
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.6K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adherence to the World Cancer Research Fund/American Institute for Cancer Research 2018 Recommendations for Cancer Prevention and Risk of Colorectal Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2019
Same author

Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer.

Gut·2019
Same author

Becoming a Statistic in the Middle of an Epidemic-A Call to Consider Alternate Risk Factors for Early-Onset Colorectal Cancer-In Reply.

JAMA oncology·2019
Same author

Mushroom consumption, biomarkers, and risk of cardiovascular disease and type 2 diabetes: a prospective cohort study of US women and men.

The American journal of clinical nutrition·2019
Same author

Mushroom Consumption and Risk of Total and Site-Specific Cancer in Two Large U.S. Prospective Cohorts.

Cancer prevention research (Philadelphia, Pa.)·2019
Same author

Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies.

JNCI cancer spectrum·2019

Related Experiment Video

Updated: Apr 19, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

14.1K

Selenium supplementation and prostate cancer mortality.

Stacey A Kenfield1, Erin L Van Blarigan2, Natalie DuPre2

  • 1Department of Urology, University of California, San Francisco, San Francisco, CA (ELVB, SAK, JMC); Department of Epidemiology, Harvard School of Public Health, Boston, MA (SAK, ND, MJS, EG); Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA (ELVB, JMC); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (MJS, EG); Department of Nutrition, Harvard School of Public Health, Boston, MA (MJS, EG). KenfieldS@urology.ucsf.edu.

Journal of the National Cancer Institute
|December 16, 2014
PubMed
Summary

High-dose selenium supplements after prostate cancer diagnosis may increase mortality risk. Caution is advised for men with prostate cancer using 140+ mcg/day of selenium supplements.

More Related Videos

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

36.2K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

48.3K

Related Experiment Videos

Last Updated: Apr 19, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

14.1K
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

36.2K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

48.3K

Area of Science:

  • Oncology
  • Nutritional Science
  • Epidemiology

Background:

  • Limited research exists on selenium supplementation's impact post-prostate cancer diagnosis.
  • Understanding the effects of selenium on prostate cancer outcomes is crucial for patient care.

Purpose of the Study:

  • To investigate the association between selenium supplement use after nonmetastatic prostate cancer diagnosis and subsequent outcomes.
  • To examine risks of prostate cancer mortality, biochemical recurrence, and cardiovascular disease mortality.

Main Methods:

  • Prospective follow-up of 4459 men diagnosed with nonmetastatic prostate cancer.
  • Utilized Cox proportional hazards models to assess selenium supplement intake (post-diagnosis) and mortality/recurrence risks.
  • Collected data on selenium from specific supplements and multivitamins.

Main Results:

  • Higher selenium intake (≥140 μg/day) was associated with a 2.60-fold increased risk of prostate cancer mortality.
  • No significant association found between selenium use and biochemical recurrence, cardiovascular disease mortality, or overall mortality.
  • Crude prostate cancer death rates were higher in men using 140+ μg/day of selenium compared to nonusers.

Conclusions:

  • Selenium supplementation of 140 μg/day or more after nonmetastatic prostate cancer diagnosis may elevate prostate cancer mortality risk.
  • Caution is recommended for men with prostate cancer regarding the use of high-dose selenium supplements.
  • Further research may be needed to clarify optimal selenium intake levels for prostate cancer patients.