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Updated: Jan 24, 2026
10:04
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
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Dietary Pattern and Risk of Multiple Myeloma in Two Large Prospective US Cohort Studies
Dong Hoon Lee1, Teresa T Fung1,2, Fred K Tabung1,3
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
JNCI Cancer Spectrum
|June 1, 2019
Summary
Diets high in inflammation and insulin resistance may increase multiple myeloma (MM) risk in men. This study found higher empirical dietary inflammatory pattern (EDIP) scores linked to increased MM risk, suggesting a potential dietary link to cancer development.
Area of Science:
- Nutrition science
- Epidemiology
- Oncology
Background:
- Limited data exists on specific dietary components and multiple myeloma (MM) risk.
- Previous studies have not investigated the association between overall dietary patterns and MM risk.
Purpose of the Study:
- To examine the association between various dietary patterns and the risk of developing multiple myeloma (MM).
Main Methods:
- Prospective cohort study involving 69,751 women and 47,232 men.
- Dietary patterns assessed using food frequency questionnaires every 4 years.
- Cox proportional hazard models used to analyze MM risk, including Alternate Healthy Eating Index-2010, Alternate Mediterranean Diet, DASH, Prudent, Western, empirical dietary inflammatory pattern (EDIP), EDIR, and EDIH.
Main Results:
- 478 incident MM cases identified during follow-up.
- In men, a high EDIP was significantly associated with a 16% increase in MM risk (HR=1.16).
- Empirical dietary indices for insulin resistance (EDIR) and hyperinsulinemia (EDIH) showed suggestive positive associations with MM risk in men.
Conclusions:
- This study provides initial evidence linking diets with higher inflammatory or insulinemic potential to MM development.
- Further research is needed to confirm these associations in diverse populations and understand the observed sex-specific differences.
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