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EV71 vaccine, an invaluable gift for children
1National Institutes for Food and Drug Control , Beijing, China.
Clinical & Translational Immunology
|December 16, 2014
Summary
This study reviews EV71 vaccine clinical trials, showing high safety and efficacy against hand, foot, and mouth disease (HFMD). It discusses challenges for integrating the EV71 vaccine into national immunization programs.
Area of Science:
- Virology
- Vaccinology
- Public Health
Background:
- Enterovirus 71 (EV71) is a primary cause of severe hand, foot, and mouth disease (HFMD).
- Developing an EV71 vaccine is crucial for preventing outbreaks and mitigating disease burden.
Purpose of the Study:
- To summarize EV71 vaccine Phase III clinical trial results.
- To discuss the integration of EV71 vaccines into national immunization programs in endemic regions.
Main Methods:
- Review of Phase I, II, and III clinical trial data for inactivated EV71 whole-virus vaccines.
- Analysis of safety, immunogenicity, and protective efficacy data from trials conducted in Asian countries.
Main Results:
- EV71 vaccines demonstrated high safety and immunogenicity in clinical trials.
- Protective efficacy against EV71-associated HFMD exceeded 90%, and against other EV71-associated diseases was over 80%.
Conclusions:
- EV71 vaccines are safe and effective, offering significant protection against EV71-related illnesses.
- Challenges exist in incorporating the EV71 vaccine into existing Expanded Program on Immunization (EPI) schedules in countries with EV71 epidemics.
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