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Published on: October 10, 2025
[Preterm birth in Bulgaria--changes in aetiology and incidence in the last decade]
Insights
Preterm birth rates are rising globally and in Bulgaria, with a significant increase in mild prematurity. This trend is linked to factors like assisted reproduction and delayed pregnancies, necessitating improved prenatal care protocols.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Research
- Public Health
Context:
- Preterm birth incidence remains high globally, despite medical advancements.
- University Maternity Hospital 'Maichin dom' observed a rise in prematurity from 11.6% (2003) to 17.5% (2013).
- Mild prematurity (first grade) saw a notable increase, from 5.8% to 10.2% of live births.
Purpose:
- To analyze trends in preterm birth rates at a leading Bulgarian maternity hospital.
- To identify contributing factors to the increasing incidence of prematurity.
- To advocate for enhanced prenatal follow-up protocols.
Summary:
- The study highlights a significant increase in preterm birth rates, particularly mild prematurity, at University Maternity Hospital 'Maichin dom' between 2003 and 2013.
- Identified causes include increased multiple pregnancies due to assisted reproductive technologies, cervical treatments (LLETZ/LEEP), delayed first pregnancies, and advanced maternal age.
- Severe prematurity rates remained stable, suggesting a shift towards earlier, less severe preterm births.
Impact:
- The findings underscore the need for revised prenatal care strategies to address the evolving landscape of preterm birth.
- Emphasizes the critical role of effective pregnancy follow-up in mitigating preterm birth risks.
- Provides data to inform public health initiatives and clinical practice guidelines for preterm birth prevention.
Abstract:
There is no decrease in the incidence of preterm birth in Bulgaria and in the world, despite of all the therapeutic and prophylactic efforts. The rate of prematurity in University Maternity Hospital 'Maichin dom' in the last decade has increased significantly- from 11.6% in 2003 to 17.5% in 2013. The numbers are higher than the national average due to the essence of the Hospital being a leading clinical and scientific center. Thorough analysis demonstrates significant increase in the first grade prematurity being 5.8% of all live births in 2003 and 10.2% of all live births in 2013. In fact 58% of all premature births result in first grade preterm newborn. There is no significant increase in the forth grade- severe prematurity in the last decade. We believe that this increase in preterm birth rate is due to several reasons: the success of assisted reproductive technologies, which in Bulgaria leads to a significant increase in the number of multiple pregnancies; destructive/ablative methods of treatment of cervical intraepithelial neoplasia, especially LLETZ (LEEP), postponing of first pregnancy, increase in the number of adult primiparous women and as a whole pregnancy at later age, pregnancy in puberty. All these impose changes in the protocol for pregnancy follow up. Furthermore, we believe it is high time to increase the effectiveness of this service, as lack of adequate follow up is a reason for preterm birth on its own.
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