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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

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[Relationship between serum histamine levels and ST-segment resolution in patients with acute myocardial infarction

S M Chen1, D Mu1, M Cui1

  • 1Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|December 17, 2014
PubMed

Insights

Higher histamine levels two hours after ST-segment elevation myocardial infarction (STEMI) percutaneous coronary intervention (PCI) indicate poorer reperfusion. Serum histamine decreased within a week post-PCI in STEMI patients.

Area of Science:

  • Cardiology
  • Biochemistry
  • Interventional Cardiology

Background:

  • Acute ST-segment elevation myocardial infarction (STEMI) requires timely reperfusion.
  • Histamine plays a role in inflammatory responses and vascular changes.
  • Understanding biomarkers associated with reperfusion is crucial for STEMI management.

Purpose of the Study:

  • To examine dynamic changes in serum histamine levels post-primary percutaneous coronary intervention (PCI) in STEMI patients.
  • To determine the association between histamine levels and ST-segment resolution after primary PCI.

Main Methods:

  • Prospective study of 84 STEMI patients undergoing primary PCI.
  • Serum histamine levels measured serially from pre-PCI to 1 week post-PCI.
  • Multivariate regression analysis to identify factors associated with ST-segment resolution.

Main Results:

  • Serum histamine levels declined in the first week following PCI.
  • Higher histamine levels at 2 hours post-PCI were linked to poorer ST-segment resolution (r=-0.361, P=0.001).
  • Other factors associated with ST-segment resolution included pain-to-balloon time, infarct-related artery, and TIMI flow grade.

Conclusions:

  • Elevated serum histamine levels 2 hours after primary PCI are an independent predictor of suboptimal myocardial reperfusion in STEMI patients.
  • Histamine may serve as a biomarker for assessing reperfusion success post-PCI.
Abstract

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