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Updated: Aug 12, 2026

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
[Acute respiratory disease caused by coronaviruses]
Serological studies found coronavirus infections in 5% of people in 1986-1987 and 7.4% in 1987-1988, with Coronaviruses 229E and OC43 identified as causes.
Area of Science:
- Virology
- Epidemiology
Context:
- Coronaviruses are a significant cause of respiratory illness.
- Understanding the prevalence and types of coronaviruses is crucial for public health.
- This study examines serological evidence of coronavirus infections over two distinct periods.
Purpose:
- To determine the serological prevalence of human coronavirus (HCoV) infections.
- To identify the specific types of coronaviruses (229E and OC43) circulating during the study periods.
- To analyze the temporal distribution of coronavirus infections.
Summary:
- Serological testing revealed coronavirus aetiology in 5% (11/218) of individuals in 1986-1987 and 7.4% (23/311) in 1987-1988.
- Human coronavirus (HCoV) 229E was more prevalent in the first period, while HCoV OC43 predominated in the second.
- Infections occurred year-round, with a notable increase in February during the 1987-1988 period.
Impact:
- Provides historical data on coronavirus circulation and seroprevalence.
- Highlights the changing prevalence of different coronavirus strains (229E and OC43).
- Informs future surveillance and control strategies for respiratory viral infections.
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